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New response surface model and its applications in aerodynamic optimization of axial compressor blade profile

LIU Xiaojia, NING Fangfei

Frontiers in Energy 2008, Volume 2, Issue 4, Pages 541-549 doi: 10.1007/s11708-008-0077-3

Abstract: Several illustrations are presented to show the fitting precision of the method.

Keywords： definition objective distribution fitting precision combination numerical aerodynamic

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Do not let precision medicine be kidnapped

Zhiping Yang

Frontiers of Medicine 2015, Volume 9, Issue 4, Pages 512-513 doi: 10.1007/s11684-015-0425-8

Abstract:

Obama’s precision medicine initiative made the medical community boil over after the initiativePrecision medicine has been advocated by the majority of scientists and doctors.This article does not oppose precision medicine.However, the incentive of vigorously promoting precision medicine at present is a concern.

Keywords： precision medicine personalized medicine genomics

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Review on the progress of ultra-precision machining technologies

Julong YUAN, Binghai LYU, Wei HANG, Qianfa DENG

Frontiers of Mechanical Engineering 2017, Volume 12, Issue 2, Pages 158-180 doi: 10.1007/s11465-017-0455-9

Abstract:

Ultra-precision machining technologies are the essential methods, to obtain the highest form accuracyThe conception, applications and history of ultra-precision machining are introduced in this article,and the developments of ultra-precision machining technologies, especially ultra-precision grinding,ultra-precision cutting and polishing are also reviewed.

Keywords： ultra-precision grinding ultra-precision cutting ultra-precision polishing research status in China development

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3D interpolation-approximation fitting construction method for complex geological surfaces

Li Mingchao,Miao Zhengjian,Liu Fei,Wang Gang

Strategic Study of CAE 2011, Volume 13, Issue 12, Pages 103-107

Abstract:

Based on multi-source data, a fitting geological surface is requiredFor the discrete data in the peripheral region, NURBS approximation fitting method is used to construct

Keywords： geological surface interpolation-approximation fitting 3D construction multi-source geological data

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Self-generation of machining precision and its realization in lapping of super precision solid balls

ZHANG Bopeng

Frontiers of Mechanical Engineering 2008, Volume 3, Issue 3, Pages 348-353 doi: 10.1007/s11465-008-0065-7

Abstract: This paper presents the principle of self-generation of machining precision by explaining its basic conceptThe self-generation of machining precision for solid balls with super precision is emphatically explainedNecessary conditions for achieving self-generation of machining precision are given.Establishment of the system for machining solid balls with super precision is discussed.Self-generation of machining precision for solid balls with super precision on the basis of the capability

Keywords： self-generation necessary self-regulation capability viewpoint Necessary

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Separation mechanism for double cylinder with shrink fitting system used for ceramics conveying rollers

Wenbin LI, Hiromasa SAKAI, Shota HARADA, Yasushi TAKASE, Nao-Aki NODA

Frontiers of Mechanical Engineering 2011, Volume 6, Issue 3, Pages 277-286 doi: 10.1007/s11465-011-0234-y

Abstract: structure was considered which has a ceramics sleeve connected with two steel shafts at both ends by shrink fittingfive times larger than that of ceramics, it is necessary to investigate how to separate the shrink fitting

Keywords： contact ceramics thermal stress heating finite element method

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Fitting on the Earth: Challenges of Carbon and Nitrogen Cycle to Preserve the Habitability of the Planet Views & Comments

Robert Socolow

Engineering 2016, Volume 2, Issue 1, Pages 21-22 doi: 10.1016/J.ENG.2016.01.012

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Human pangenome: far-reaching implications in precision medicine

Frontiers of Medicine doi: 10.1007/s11684-023-1039-1

Abstract: Human pangenome: far-reaching implications in precision medicine

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Investigating peak stresses in fitting and repair patches of buried polyethylene gas pipes

Reza KHADEMI ZAHEDI, Pouyan ALIMOURI, Hooman KHADEMI ZAHEDI, Mohammad SHISHESAZ

Frontiers of Structural and Civil Engineering 2020, Volume 14, Issue 1, Pages 147-168 doi: 10.1007/s11709-019-0587-6

Abstract: According to the results, the peak stress values take place in the middle of the fitting and at its internalThe maximum stress values in fitting and pipe are below the allowable stresses which shows the properuse of introduced fitting is applicable even in hot climate areas of Ahvaz, Iran.

Keywords： Ansys software polyethylene buried pipelines polyethylene joints polyethylene patches peak von Mises stress soil-pipe interaction temperature variation

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Highlights in precision agriculture

Chunjiang ZHAO, Minzan LI

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 391-392 doi: 10.15302/J-FASE-2018246

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High resolution satellite imaging sensors for precision agriculture

Chenghai YANG

Frontiers of Agricultural Science and Engineering 2018, Volume 5, Issue 4, Pages 393-405 doi: 10.15302/J-FASE-2018226

Abstract:

The central concept of precision agriculture is to manage within-field soil and crop growth variabilityRemote sensing has been an integral part of precision agriculture since the farming technology startedagricultural applications over large geographic areas since the 1970s, but they have limited use for precisionaerial coverage, make high resolution satellite sensors attractive for many applications, including precisionThe applications of these sensors for precision agriculture are reviewed and application examples based

Keywords： high resolution satellite sensor multispectral imagery precision agriculture spatial resolution temporal

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Molecular classification and precision therapy of cancer: immune checkpoint inhibitors

Yingyan Yu

Frontiers of Medicine 2018, Volume 12, Issue 2, Pages 229-235 doi: 10.1007/s11684-017-0581-0

Abstract:

On May 23, 2017, the US Food and Drug Administration (FDA) approved a treatment for cancer patients with positive microsatellite instability-high (MSI-H) markers or mismatch repair deficient (dMMR) markers. This approach is the first approved tumor treatment using a common biomarker rather than specified tumor locations in the body. FDA previously approved Keytruda for treatment of several types of malignancies, such as metastatic melanoma, metastatic non-small-cell lung cancer, recurrent or metastatic head and neck cancer, refractory Hodgkin lymphoma, and urothelial carcinoma, all of which carry positive programmed death-1/programmed death-ligand 1 biomarkers. Therefore, indications of Keytruda significantly expanded. Several types of malignancies are disclosed by MSI-H status due to dMMR and characterized by increased neoantigen load, which elicits intense host immune response in tumor microenvironment, including portions of colorectal and gastric carcinomas. Currently, biomarker-based patient selection remains a challenge. Pathologists play important roles in evaluating histology and biomarker results and establishing detection methods. Taking gastric cancer as an example, its molecular classification is built on genome abnormalities, but it lacks acceptable clinical characteristics. Pathologists are expected to act as “genetic interpreters” or “genetic translators” and build a link between molecular subtypes with tumor histological features. Subsequently, by using their findings, oncologists will carry out targeted therapy based on molecular classification.

Keywords： molecular classification precision medicine pembrolizumab PD-1/PD-L1 MSI-H

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ECRG4: a new potential target in precision medicine

Xin Qin, Ping Zhang

Frontiers of Medicine 2019, Volume 13, Issue 5, Pages 540-546 doi: 10.1007/s11684-018-0637-9

Abstract: Given the rapid development in precision medicine, tremendous efforts have been devoted to discoveringcell membrane upon activation and detected in liquid biopsy, thus offering considerable potential in precisionThe future perspectives of ECRG4 as a potential molecular marker in precision medicine are also discussed

Keywords： ECRG4 tumor suppressor gene sentinel molecule precision medicine cell senescence epithelium homeostasis

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Application of liquid biopsy in precision medicine: opportunities and challenges

Junyun Wang, Shuang Chang, Guochao Li, Yingli Sun

Frontiers of Medicine 2017, Volume 11, Issue 4, Pages 522-527 doi: 10.1007/s11684-017-0526-7

Abstract:

Precision medicine for cancer patients aims to adopt the most suitable treatment options during diagnosisThey could also provide the ideal scheme to personalize treatment in precision medicine.

Keywords： liquid biopsy circulating tumor cells cell-free ctDNA exosomes precision medicine